To investigate these mechanisms, we combined DISC1 truncated transgenic mice, opto chemogenetic manipulations, slice electrophysiology, and behavioral analyses to demonstrate that 1 DISC1 N TM mice have an impairment in risk avoidance, 2 dysfunction of NAc fast spiking PV neurons is responsible for the deficits in risk avoidance, and 3 optogenetic activation of NAc PV neurons rescues the impaired risk avoidance behavior in DISC1 N TM mice cialis pills
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To investigate these mechanisms, we combined DISC1 truncated transgenic mice, opto chemogenetic manipulations, slice electrophysiology, and behavioral analyses to demonstrate that 1 DISC1 N TM mice have an impairment in risk avoidance, 2 dysfunction of NAc fast spiking PV neurons is responsible for the deficits in risk avoidance, and 3 optogenetic activation of NAc PV neurons rescues the impaired risk avoidance behavior in DISC1 N TM mice cialis pills